The AI sector maintained robust momentum entering 2025. The pace of activity did not decelerate throughout the year. Although fewer companies secured individual funding rounds exceeding $1 billion—with Anthropic being a notable exception, raising two such rounds—a significant trend emerged: more companies closed multiple funding rounds compared to 2024, with the count rising to eight.

The outlook for 2026 appears similarly vigorous based on early indicators. In the initial weeks of the year, Elon Musk's xAI announced a massive $20 billion Series E round, while Sam Altman's brain-computer interface venture, Merge Labs, secured a $250 million seed round led by OpenAI. It remains early in the year, but these developments suggest another period of strong growth lies ahead. The following is a comprehensive list of U.S. AI companies that raised at least $100 million in 2025, organized by month.

**December**

On December 17, Austin-based Mythic, a developer of power-efficient AI compute solutions, closed a $125 million venture round led by DCVC. Other investors included SoftBank, NEA, and Linse Capital.

Chai Discovery, which builds AI models for biotechnology and drug discovery, announced a $130 million Series B on December 15, achieving a $1.2 billion valuation. Oak HC/FT and General Catalyst co-led the round.

The generative media platform Fal announced its third funding round of the year on December 9: a $140 million Series D led by Sequoia that valued the company at over $4.5 billion.

Unconventional AI, a startup rethinking computer foundations for the AI age, revealed a monumental $475 million seed round on December 8. Led by Lightspeed Venture Partners and Andreessen Horowitz, the round valued the one-year-old company at nearly $4.5 billion.

Boston-based 7AI, which develops cybersecurity AI agents, raised a $130 million Series A round announced on December 4. Index Ventures led the investment, with participation from Greylock, Spark Capital, and CRV.

**November**

Genspark, an all-in-one AI workspace platform, announced a $275 million Series B on November 20, reaching a $1.25 billion valuation. Investors included Emergence Capital Partners, SBI Investment, and LG Technology Ventures.

Luma AI, creator of models for photo and video generation, raised $900 million in a Series C round that valued the startup at $4 billion. The round was led by Humain, with Andreessen Horowitz, AMD Ventures, and Amplify Partners participating.

Anysphere, the company behind the viral coding platform Cursor, secured $2.3 billion in a funding round announced on November 13, valuing the company at $29.3 billion. This marked its second round of the year.

Parallel, which builds web infrastructure for AI agents, announced a $100 million Series A on November 12, co-led by Index Ventures and Kleiner Perkins.

Healthcare AI agent startup Hippocratic AI raised a $126 million Series C on November 3, reaching a $3.5 billion valuation. This was its second round of the year and was led by Avenir Growth.

**October**

Fireworks AI, a platform for building applications with open-source models, announced a $250 million Series C on October 28, achieving a $4 billion valuation.

Enterprise AI startup Uniphore reached a $2.5 billion valuation following a $260 million Series F round announced on October 22. Investors included Snowflake Ventures, Nvidia, Databricks Ventures, and AMD.

Voice AI company Sesame raised a $250 million Series B co-led by Sequoia and Spark Capital, announced on October 21, with SignalRank also participating.

Cambridge, Massachusetts-based OpenEvidence, developer of an AI medical chatbot, announced its second 2025 round on October 20: a $200 million Series C that valued the company at $6 billion.

Lila Sciences, aiming to build a science superintelligence platform, announced its second 2025 round on October 14—a $350 million Series A co-led by Braidwell and Collective Global.

Reflection AI, a competitor to DeepSeek, announced its second mega-round of the year on October 9: a $2 billion Series B led by Nvidia that valued the company at $8 billion.

EvenUp, which creates AI for personal injury law, announced a $150 million Series E on October 7, valuing the company at over $2 billion. The round was led by Bessemer, with Lightspeed, Bain Capital, and SignalFire participating.

**September**

Periodic Labs, which is building an AI scientist, announced a $300 million seed round on September 30. Felicis and Andreessen Horowitz led the round, with Nvidia, Lightspeed, and Khosla Ventures participating.

AI infrastructure company Cerebras Systems raised a $1.1 billion Series G on September 30, reaching an $8.1 billion valuation. The round was co-led by Fidelity and Atreides Management.

Modular announced a $250 million funding round on September 24, led by US Innovative Technology Fund, with GV, Greylock, and General Catalyst participating.

Distyl AI, a builder of enterprise AI software, raised a $175 million Series B on September 23, achieving a $1.8 billion valuation. Investors included Khosla Ventures and Lightspeed.

AI infrastructure startup Upscale AI raised a $100 million seed round on September 17, co-led by Maverick Silicon and Mayfield, with StepStone Group, Stanford University, and Qualcomm Ventures participating.

AI inference company Groq raised a $750 million Series D-3 on September 17, valuing the company at nearly $6.9 billion. The round was led by Disruptive.

AI training startup Invisible Technologies reached a $2 billion valuation after a $100 million fundraise announced on September 16, led by Vanara Capital with participation from Greycroft, Tallwoods Capital, and Freestyle Capital.

Cognition AI, creator of the coding agent Devin, raised a $400 million Series C on September 8, led by Founders Fund, valuing the company at $10.2 billion.

AI infrastructure startup Baseten raised a $150 million Series D on September 5, reaching a $2.1 billion valuation. The round was led by Bond, with CapitalG, IVP, and Spark Capital participating.

Bret Taylor's customer service AI platform Sierra raised $350 million in a round led by Greenoaks Capital, announced on September 4, valuing the company at over $10 billion.

Personalized AI search engine You.com raised a $100 million Series C led by Cox Enterprises on September 3, achieving a $1.5 billion valuation.

AI research lab Anthropic announced its second 2025 round on September 2: a $13 billion Series F led by Iconiq, Fidelity, and Lightspeed, valuing the company at $183 billion.

**August**

Healthcare and housing automation platform EliseAI raised $250 million in a Series E on August 20, reaching a $2.2 billion valuation. The round was led by Andreessen Horowitz.

AI research lab Decart raised $100 million at a $3.1 billion valuation on August 7. Investors included Sequoia Capital, Benchmark, and Zeev Ventures.

**July**

Generative media platform Fal raised a $125 million Series C on July 31, led by Meritech Capital Partners, valuing the company at $1.5 billion. Salesforce Ventures, Shopify Ventures, and Google AI Futures Fund participated.

Ambience Healthcare, building an AI healthcare operating system, raised a $243 million Series C co-led by Oak HC/FT and Andreessen Horowitz. Kleiner Perkins, OpenAI Startup Fund, and Smash Capital also participated.

AI research lab Reka AI raised $110 million in a Series B on July 22, reaching a $1 billion valuation. Investors included Snowflake and Nvidia.

Thinking Machines Lab confirmed a $2 billion seed round on July 15, led by Andreessen Horowitz with Nvidia, Accel, and AMD participating, valuing the company at $12 billion.

Cambridge-based OpenEvidence, building an AI search tool for clinicians, raised $210 million in a Series B on July 15 at a $3.5 billion valuation. The round was led by Kleiner Perkins and GV.

Harmonic, developing a mathematical reasoning engine, raised a $100 million Series B led by Kleiner Perkins on July 10, valuing the company at $875 million.

**June**

Healthcare AI unicorn Abridge raised a $300 million Series E, reaching a $5.3 billion valuation. The round was led by Andreessen Horowitz with Khosla Ventures participating, marking its second round of 2025.

Legal AI tools company Harvey announced its second $300 million round of the year on June 23. This Series E was co-led by Kleiner Perkins and Coatue, bringing the valuation to $5 billion.

Healthcare AI startup Tennr raised a $101 million Series C led by IVP on June 23, with Lightspeed Venture Partners, GV, and Andreessen Horowitz participating, valuing the company at $605 million.

Enterprise search startup Glean announced a $150 million Series F on June 10, led by Wellington Management with Sequoia, Lightspeed, and Kleiner Perkins participating, achieving a $7.25 billion valuation.

Anysphere raised a $900 million Series C on June 5, led by Thrive Capital with Andreessen Horowitz, Accel, and DST Global participating, valuing the company at nearly $10 billion.

**May**

AI data labeling startup Snorkel AI announced a $100 million Series D on May 29, reaching a $1.3 billion valuation. The round was led by Addition, with Prosperity7 Ventures, Lightspeed, and Greylock participating.

Community-driven AI benchmarking tool LMArena raised a $100 million seed round on May 21, valued at $600 million. The round was co-led by Andreessen Horowitz and UC Investments, with Lightspeed, Kleiner Perkins, and Felicis participating.

Las Vegas-based AI infrastructure company TensorWave raised a $100 million Series A on May 14, co-led by Magnetar Capital and AMD Ventures, with Prosperity7 Ventures, Nexus Venture Partners, and Maverick Silicon participating.

**April**

SandboxAQ closed a $450 million Series E on April 4, valuing the AI model company at $5.7 billion. Investors included Nvidia, Google, and Bridgewater Associates founder Ray Dalio.

Runway, which creates AI models for media production, raised a $308 million Series D on April 3, reaching a $3 billion valuation. The round was led by General Atlantic, with SoftBank, Nvidia, and Fidelity participating.

**March**

AI behemoth OpenAI raised a record-breaking $40 billion funding round on March 31, achieving a $300 billion valuation. The round was led by SoftBank, with Thrive Capital, Microsoft, and Coatue participating.

AI infrastructure company Nexthop AI announced a $110 million Series A on March 25, led by Lightspeed Venture Partners, with Kleiner Perkins, Battery Ventures, and Emergent Ventures participating.

Cambridge-based Insilico Medicine raised $110 million in a Series E on March 13 for its generative AI drug discovery platform, reaching a $1 billion valuation. The round was co-led by Value Partners and Pudong Chuangtou.

AI infrastructure company Celestial AI raised a $250 million Series C on March 11, valued at $2.5 billion. The round was led by Fidelity, with Tiger Global, BlackRock, and Intel CEO Lip-Bu Tan participating.

Lila Sciences raised a $200 million seed round to create a science superintelligence platform, led by Flagship Pioneering. The Cambridge-based company also received funding from March Capital, General Catalyst, and ARK Venture Fund.

Brooklyn-based Reflection.Ai, building superintelligent autonomous systems, raised a $130 million Series A on March 7, valuing the one-year-old company at $580 million. The round was led by Lightspeed Venture Partners and CRV.

AI coding startup Turing closed a $111 million Series E on March 7, valued at $2.2 billion. The round was led by Khazanah Nasional, with WestBridge Capital, Gaingels, and Sozo Ventures participating.

Defense tech startup Shield AI raised $240 million in a Series F on March 6, valued at $5.3 billion. The round was co-led by L3Harris Technologies and Hanwha Aerospace, with Andreessen Horowitz and the US Innovative Technology Fund participating.

Anthropic raised $3.5 billion in a Series E on March 3, reaching a $61.5 billion valuation. The round was led by Lightspeed, with Salesforce Ventures, Menlo Ventures, and General Catalyst participating.

**February**

Together AI, creating open-source generative AI infrastructure, raised a $305 million Series B on February 20, valued at $3.3 billion. The round was co-led by Prosperity7 and General Catalyst, with Salesforce Ventures, Nvidia, and Lux Capital participating.

AI infrastructure company Lambda raised a $480 million Series D on February 19, valued at nearly $2.5 billion. The round was co-led by SGW and Andra Capital, with Nvidia, G Squared, and ARK Invest participating.

Abridge raised a $250 million Series D on February 17, valued at $2.75 billion. The round was co-led by IVP and Elad Gil, with Lightspeed, Redpoint, and Spark Capital participating.

AI legal tech company Eudia raised $105 million in a Series A led by General Catalyst on February 13. Floodgate, Defy Ventures, and Everywhere Ventures also participated.

AI hardware startup EnCharge AI raised a $100 million Series B on February 13, led by Tiger Global with Scout Ventures, Samsung Ventures, and RTX Ventures participating. The Santa Clara-based company was founded in 2022.

Legal AI company Harvey raised a $300 million Series D on February 12, valued at $3 billion. The round was led by Sequoia, with OpenAI Startup Fund, Kleiner Perkins, and Elad Gil participating.

**January**

Synthetic voice startup ElevenLabs raised a $180 million Series C on January 30, valued at over $3 billion.